CHR-P programme

What if we could intervene before psychosis?

NWPharmaTech’s clinical high-risk for psychosis (CHR-P) programme is investigating NWPT-SM32300 — an investigational CBD micellar-emulsion softgel — with Professor Scott Woods as programme lead.

Investigational — effectiveness in this population has not been established.

Image caption: Conceptual neural motif for early CNS research — not evidence of targeting or clinical benefit.

Clinical need

Why early intervention matters

Clinical high risk for psychosis (CHR-P) identifies people with elevated transition risk relative to the general population. It is not a diagnosis of schizophrenia, and it does not mean any individual will inevitably develop psychosis. An updated meta-analysis estimated that about one in four people identified as CHR-P (pooled estimate, 25%) developed psychosis within three years — while most do not (Salazar de Pablo et al., 2021, JAMA Psychiatry). UK NICE guidance emphasises specialist assessment and psychological care — and does not recommend antipsychotics to prevent psychosis in the at-risk group.

Current programme

Status: planned Phase 2B · investigational

What the planned study asks

Investigational NWPT-SM32300 (300 mg CBD micellar-emulsion softgel) in people at clinical high risk: dose response, symptoms, safety and tolerability — approximately 328 participants, 12 weeks + week 16 follow-up. Effectiveness has not been established. Prevention is not the current primary aim.

Conceptual cyan and amber investigational softgel on a dark background.
Conceptual illustration of the investigational softgel — not a final commercial product and not a product photograph of NWPT-SM32300.
Proposed Phase 2B design — investigational. Effectiveness not established. Not a locked protocol.
  1. Population People meeting defined CHR-P criteria
  2. Randomisation Four arms · N≈328 · placebo · 300 · 600 · 900 mg
  3. Treatment 12 weeks once daily
  4. Follow-up Week 16
  5. Analyses Dose response · symptoms · safety · tolerability

Scientific leadership

Scientific leadership

Programme scientific leadership for CHR-P and related psychiatric development. Roles are individual scientific and company roles — not institutional endorsements of this website or any financing vehicle.

Professor Scott Woods

CHR-P programme lead Individual capacity

Clinical high-risk-for-psychosis expertise supporting early identification, assessment, and intervention research. Yale University does not sponsor or endorse this website, the DAO, or any financing vehicle.

Dr Grace Blest-Hopley

Partner & Chief Scientific Officer

Company scientific leadership for NWPharmaTech’s research and development agenda, including the investigational CHR-P candidate.

Dr John Kane, MD

Lead — Schizophrenia Programme

Senior psychiatric leadership for the company’s schizophrenia development strategy and clinical programme.

Funding overview

How catalytic capital could help

We are evaluating a platform-supported route for eligible investors to help finance the CHR-P research programme, including a permissioned digital record of participation at closing where that proves feasible. If a platform path cannot meet legal, operational or investor-access requirements, a conventional private placement with a legal investor register remains the fallback. These are development objectives, not live offering terms. Neither path is available on this website: production investment, payment and token issuance remain inactive. Community updates and discussion are separate from any regulated investment process.

Any ~US$10 million figure is a planning target only — not money already raised, and not a claim that catalytic capital fully funds the Phase 2B programme.